A cell-permeant inhibitor of NFAT signaling
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NFAT Activation Inhibitor III

Item No. 21812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,10-dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
CAS Number
3519-82-2
Synonyms
  • INCA-6
  • NSC 25996
  • Nuclear Factor of Activated T cells Inhibitor III
Molecular Formula
C20H12O2
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 2 mg/mL
λmax
210, 252 nm
SMILES
O=C(C1=C2C3C4=CC=CC=C4C1C5=CC=CC=C53)C=CC2=O
InChi Code
InChI=1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H
InChi Key
GCHPUOHXXCNSQL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $297

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    50 mg

    $525

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    Product Description

    NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).1 It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.1 NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roehrl, M.H.A., Kang, S., Aramburu, J., et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc. Natl. Acad. Sci. USA 101(20), 7554-7559 (2004).