A cell-permeant inhibitor of NFAT signaling
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NFAT Activation Inhibitor III

Item No. 21812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,10-dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
CAS Number
3519-82-2
Synonyms
  • INCA-6
  • NSC 25996
  • Nuclear Factor of Activated T cells Inhibitor III
Molecular Formula
C20H12O2
Formula Weight
284.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 2 mg/mL
λmax
210, 252 nm
SMILES
O=C(C1=C2C3C4=CC=CC=C4C1C5=CC=CC=C53)C=CC2=O
InChi Code
InChI=1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H
InChi Key
GCHPUOHXXCNSQL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $127

    Add

    25 mg

    $297

    Add

    50 mg

    $525

    Add
    Product Description

    NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT).1 It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 µM), preventing it from binding and dephosphorylating NFAT.1 NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin (Item No. 10004974). It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roehrl, M.H.A., Kang, S., Aramburu, J., et al. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc. Natl. Acad. Sci. USA 101(20), 7554-7559 (2004).