A DOPA decarboxylase inhibitor
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Metabolite(s)
195223',4'-Dihydroxyphenylacetone
Pro-drug Form(s)
24002Methyldopate
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L-(−)-α-Methyldopa

Item No. 21814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-α-methyl-L-tyrosine
CAS Number
555-30-6
Synonyms
  • Methyldopa
  • MK-351
  • NSC 169916
Molecular Formula
C10H13NO4
Formula Weight
211.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: sparingly soluble
λmax
224, 284 nm
SMILES
OC1=C(O)C=CC(C[C@](C)(N)C(O)=O)=C1
InChi Code
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
InChi Key
CJCSPKMFHVPWAR-JTQLQIEISA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $69

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    10 g

    $120

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    25 g

    $263

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    50 g

    $461

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    Product Description

    L-(−)-α-Methyldopa is a dopamine (DOPA) decarboxylase inhibitor (ED50 = 21.8 mg/kg) and has antihypertensive activity in vitro and in vivo.1,2,3 L-(−)-α-Methyldopa enters the CNS and is metabolized to form α-methylnorepinephrine which acts as an agonist at α2-adrenergic receptors.1,3 Formulations containing L-(−)-α-methyldopa are used to lower blood pressure.2 L-(−)-α-Methyldopa also improves trophoblast and endothelial cellular interactions in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, B., Bobek, G., Makris, A., et al. Antihypertensive methyldopa, labetalol, hydralazine, and clonidine reversed tumour necrosis factor-α inhibited endothelial nitric oxide synthase expression in endothelial-trophoblast cellular networks. Clin. Exp. Pharmacol. Physiol. 44(3), 421-427 (2016).

    2. Onesti, G., Brest, A.N., Novack, P., et al. Pharmacodyamic effects of alpha-methyl dopa in hypertensive subjects. Am. Heart J. 67(1), 32-38 (1964).

    3. LeDoux, J.E., Sakaguchi, A., and Reis, D.J. Alpha-methylDOPA dissociates hypertension, cardiovascular reactivity and emotional behavior in spontaneously hypertensive rats. Brain Res. 259(1), 69-76 (1983).