An inhibitor of Cdk1, Cdk5, and GSK3
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Aloisine RP106

Item No. 21873

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
CAS Number
496864-15-4
Molecular Formula
C17H19N3O
Formula Weight
281.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 12 mg/ml
λmax
260, 354 nm
SMILES
COC(C=C1)=CC=C1C2=C(CCCC)C3=NC=CN=C3N2
InChi Code
InChI=1S/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20)
InChi Key
WVMANZPBOBRWCB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $169

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    10 mg

    $253

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    25 mg

    $567

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    Product Description

    Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 µM, respectively).1 It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mettey, Y., Gompel, M., Thomas, V., et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J. Med. Chem. 46(2), 222-236 (2003).