Sulfamethoxypyridazine

Sulfamethoxypyridazine is a sulfonamide antibiotic that inhibits the growth of Gram-negative bacteria and other microorganisms.^1,2,3,4 It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC₅₀ = 17 nM) and folate biosynthesis in P. carinii by 75% when used at a concentration of 50 nM.¹ Sulfamethoxypyridazine (0.25 mg/ml) inhibits any visible growth in culture tubes of 378 out of 530 E. coli isolates from necropsied animals and poultry.² It also decreases the number of viable amoxicillin-induced B. burgdorferi round body forms to 30% of control when used at a concentration of 50 μM.³ In vivo, sulfamethoxypyridazine decreases the number of P. carinii trophozoite and cyst lesions in lung tissue in a mouse model of pneumonia infection (ED₅₀s = 0.06 and 0.08 mg/kg per day, respectively).⁴

WARNING This product is not for human or veterinary use.

1. Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 39(8), 1756-1763 (1995).

2. Glantz, P.J. In vitro sensitivity of Escheria coli to sulfonamides. Cornell Vet. 55, 9-18 (1965).

3. Feng, J., Shi, W., Zhang, S., et al. A drug combination screen identifies drugs active against amoxicillin-induced round bodies of in vitro Borrelia burgdorferi persisters from an FDA drug library. Front. Microbiol. 7:743, (2016).

4. Bartlett, M.S., Shaw, M.M., Smith, J.W., et al. Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 42(4), 934-935 (1998).