A Kir6.2/SUR1 activator
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VU0071063

Item No. 21897

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
333415-38-6
Molecular Formula
C18H22N4O2
Formula Weight
326.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/ml
λmax
273 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
InChi Code
InChI=1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
InChi Key
ZFZAIHKQJBMYLO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    25 mg

    $462

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 µM using whole cell patch clamp electrophysiology).1 It is selective for SUR1-containing Kir6.1 or Kir6.2 channels over SUR2A, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raphemot, R., Swale, D.R., Dadi, P.K., et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol. Pharmacol. 85(6), 858-865 (2014).