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3-Fluorofentanyl (hydrochloride)

Item No. 21952

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 3-Fluorofentanil
  • ​NFEPP
Technical Information
Formal Name
N-[3-fluoro-1-(2-phenylethyl)-4-piperidinyl]-N-phenyl-propanamide, monohydrochloride
CAS Number
2309383-04-6
Molecular Formula
C22H27FN2O • HCl
Formula Weight
390.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CC)N(C1CCN(CCC2=CC=CC=C2)CC1F)C3=CC=CC=C3.Cl
InChi Code
InChI=1S/C22H27FN2O.ClH/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18;/h3-12,20-21H,2,13-17H2,1H3;1H
InChi Key
BZUDTUIZEQBTFJ-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    3-Fluorofentanyl (hydrochloride) (Item No. 21952) is an analytical reference standard categorized as an opioid.1,2 3-Fluorofentanyl reduces acute and persistent pain selectively in injured areas, without adverse effects common to opiates, such as sedation, constipation, and lowered respiratory rate, in rats.1 It is also without rewarding effects in an unbiased conditioned place preference test at a dose that would be lethal for fentanyl (Item Nos. ISO60197 | 23580 | 14719) in rats. 3-Fluorofentanyl is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Spahn, V., Del Vecchio, G., Labuz, D., et al. A nontoxic pain killer designed by modeling of pathological receptor conformations. Science 355(6328), 966-969 (2017).

    2. Edwards, S.R., Blough, B.E., Cowart, K., et al. Assessment of the antinociceptive, respiratory-depressant, and reinforcing effects of the low pKa fluorinated fentanyl analogs, FF3 and NFEPP. Neuropharmacology 255, 110002 (2024).