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Fentanyl

Item No. 23580

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide
CAS Number
437-38-7
Molecular Formula
C22H28N2O
Formula Weight
336.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
SMILES
O=C(N(C1=CC=CC=C1)C2CCN(CCC3=CC=CC=C3)CC2)CC
InChi Code
InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
InChi Key
PJMPHNIQZUBGLI-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    Product Description

    Fentanyl (Item No. 23580) is an analytical reference standard categorized as an opioid.1,2 It is more effective than morphine (Item No. ISO60147) at reducing pain but is also more lethal.3 Fentanyl is highly abused and is associated with many fatal overdoses.4 Fentanyl is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burns, S.M., Cunningham, C.W., and Mercer, S.L. DARK classics in chemical neuroscience: Fentanyl. ACS Chem. Neurosci. 9(10), 2428-2437 (2018).

    2. Raynor, K., Kong, H., Chen, Y., et al. Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol. Pharm. 45(2), 330-334 (1994).

    3. Higashikawa, Y., and Suzuki, S. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues. Forensic Toxicol. 26(1), 1-5 (2008).

    4. Armenian, P., Vo, K.T., Barr-Walker, J., et al. Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review. Neuropharmacology 134(Pt A), 121-132 (2018).

    Product Citations

    Truver, M.T., Roman, M., Gomonit, M.M., et al. Fatal intoxications with nitazenes: Postmortem findings, toxicology, and in vitro characterization at the μ-opioid receptor of six nitazene analogues. Arch. Toxicol. (2026).

    Berardinelli, D., Taoussi, O., Ovat, D.Y., et al. Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. Arch. Toxicol. (2025).

    Vandeputte, M.M., Bilel, S., Tirri, M., et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology 260, 110113 (2024).

    Monti, M.C., De Vrieze, L.M., Vandeputte, M.M., et al. Detection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole "nitazene" class. J. Pharm. Biomed. Anal. 251:116453, (2024).

    Vandeputte, M.M., Walton, S.E., Shuda, S.A., et al. Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs. Anal. Bioanal. Chem. (2023).

    Vandeputte, M.M., Krotulski, A.J., Walther, D., et al. Pharmacological evaluation and forensic case series of N‑pyrrolidino etonitazene (etonitazepyne), a newly emerging 2‑benzylbenzimidazole ‘nitazene’ synthetic opioid. Arch. Toxicol. 96, 1845-1863 (2022).

    Vandeputte, M.M., Verougstraete, N., Walther, D., et al. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass. Arch. Toxicol. 96(6), 1865-1880 (2022).

    Hassanien, S.H., Bassman, J.R., Perrien Naccarato, C.M., et al. In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis. Drug Test. Anal. 12(8), 1212-1221 (2020).

    Blanckaert, P., Cannaert, A., Van Uytfanghe, K., et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. Drug Test. Anal. 12(4), 422-430 (2019).