A CCR2 antagonist
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PF-4136309

Item No. 21965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-benzamide
CAS Number
1341224-83-6
Synonyms
  • INCB 8761
Molecular Formula
C29H31F3N6O3
Formula Weight
568.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 5 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.17 mg/ml
λmax
250 nm
SMILES
O=C(CNC(C1=CC(C(F)(F)F)=CC=C1)=O)N2C[C@@H](N[C@]3([H])CC[C@@](C4=CC=C(C5=NC=CC=N5)C=N4)(O)CC3)CC2
InChi Code
InChI=1S/C29H31F3N6O3/c30-29(31,32)21-4-1-3-19(15-21)27(40)36-17-25(39)38-14-9-23(18-38)37-22-7-10-28(41,11-8-22)24-6-5-20(16-35-24)26-33-12-2-13-34-26/h1-6,12-13,15-16,22-23,37,41H,7-11,14,17-18H2,(H,36,40)/t22-,23-,28-/m0/s1
InChi Key
ZNSVOHSYDRPBGI-LXWOLXCRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively).1 It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 µM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, C.-B., Wang, A., Han, Q., et al. Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist. ACS Med. Chem. Lett. 2(12), 913-918 (2011).