An adenosine A1 receptor antagonist
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DPCPX

Item No. 21972

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione
CAS Number
102146-07-6
Synonyms
  • 8-Cyclopentyl-1,3-dipropylxanthine
  • 1,3-Dipropyl-8-cyclopentylxanthine
  • PD 116948
Molecular Formula
C16H24N4O2
Formula Weight
304.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(C(N=C(C1CCCC1)N2)=C2N3CCC)N(CCC)C3=O
InChi Code
InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChi Key
FFBDFADSZUINTG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $33

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    25 mg

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    50 mg

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    Product Description

    DPCPX is an adenosine A1 receptor antagonist (Ki = 0.3 nM).1 It is selective for the adenosine A1 receptor over the adenosine A2 receptor (Ki = 340 nM). DPCPX (0.03 and 1 µM) increases the force of contractions in isolated guinea pig left auricles and inhibits decreases in contraction forces induced by the adenosine receptor agonists (–)-N6-phenylisopropyladenosine (PIA) or 5'-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in isolated guinea pig papillary muscles (pA2s = 9.3 and 9, respectively).2 It reverses cardiac arrest induced by adenosine, the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; Item No. 21448), or the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in isolated rat atrium.3 DPCPX (2 and 4 mg/kg) decreases immobility time in the forced swim test and tail suspension test in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lohse, M.J., Klotz, K.N., Lindenborn-Fotinos, J., et al. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) – a selective high affinity antagonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 336(2), 204-210 (1987).

    2. von der Leyen, H., Schmitz, W., Scholz, H., et al. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch. Pharmacol. 340(2), 204-209 (1989).

    3. Camara, H., da Silva, E.D., Jr., Garcia, A.G., et al. Cardiac arrest induced by muscarinic or adenosine receptors agonists is reversed by DPCPX through double mechanism. Eur. J. Pharmacol. 819, 9-15 (2018).

    4. Szopa, A., Poleszak, E., Bogatko, K., et al. DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests. Naunyn Schmiedebergs Arch. Pharmacol. 391(12), 1361-1371 (2018).