A quaternary ammonium-containing cationic surfactant with broad-spectrum antiseptic activities
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Cetylpyridinium (chloride)

Item No. 21983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-hexadecyl-pyridinium, monochloride
CAS Number
123-03-5
Synonyms
  • Hexadecylpyridinium
Molecular Formula
C21H38N • Cl
Formula Weight
340.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
203, 260 nm
SMILES
CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]
InChi Code
InChI=1S/C21H38N.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;/h15,17-18,20-21H,2-14,16,19H2,1H3;1H/q+1;/p-1
InChi Key
YMKDRGPMQRFJGP-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $29

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    Cayman Chemical
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    Product Description

    Cetylpyridinium is a quaternary ammonium-containing cationic surfactant with broad-spectrum antiseptic activities.1 It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 µg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 µg/ml).2 Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huyck, C.L. The effect of cetylpyridinium chloride on the bacterial growth in the oral cavity. J. Am. Pharm. Assoc. 34(1), 5-11 (1945).

    2. Roberts, W.R., and Addy, M. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. J. Clin. Periodontol. 8(4), 295-310 (1981).

    3. Schemehorn, B.R., McDonald, J.L., Stookey, G.K., et al. An incisor plaque model in rats. J. Dent. Res. 63(1), 32-36 (1984).