A partial antagonist of mGluR5
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VU0029251

Item No. 21987

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dihydro-2-(methylthio)-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
CAS Number
330819-85-7
Molecular Formula
C10H11N3S2
Formula Weight
237.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 20mg/mLPBS (pH 7.2): insolube
λmax
241, 287 nm
SMILES
CSC1=NC(N)=C(C(CCC2)=C2S3)C3=N1
InChi Code
InChI=1S/C10H11N3S2/c1-14-10-12-8(11)7-5-3-2-4-6(5)15-9(7)13-10/h2-4H2,1H3,(H2,11,12,13)
InChi Key
WDDBZCKBRCTSOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $422

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    Product Description

    VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; Ki = 1.07 µM).1 It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC50 = 1.7 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78(6), 1105-1123 (2010).