An Analytical Reference Standard
Related Products
Certified Reference Material(s)
43236Lormetazepam (CRM) 44677Lormetazepam (CRM)
Parent Compound(s)
15554Diclazepam 28623Diclazepam (CRM)
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Lormetazepam

Item No. 21989

Restricted Product (Schedule IV)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • N-methyl Lorazepam
  • Ro 5-5516
  • Wy 4082
Technical Information
Formal Name
7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
CAS Number
848-75-9
Molecular Formula
C16H12Cl2N2O2
Formula Weight
335.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
ClC1=CC(C(C2=CC=CC=C2Cl)=NC3O)=C(C=C1)N(C)C3=O
InChi Code
InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
InChi Key
FJIKWRGCXUCUIG-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
IV
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Lormetazepam (Item No. 21989) is an analytical reference standard categorized as a benzodiazepine.1 Lormetazepam is an active metabolite of diclazepam (Item Nos. 28623 | 15554) and is associated with misuse.2,3 Formulations containing lormetazepam have been used in the treatment of insomnia. Lormetazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hümpel, M., Illi, V., Milius, W., et al. The pharmacokinetics and biotransformation of the new benzodiazepine lormetazepam in humans. I. Absorption, distribution, elimination and metabolism of lormetazepam-5-14C. Eur. J. Drug Metab. Pharmacokinet. 4(4), 237-243 (1979).

    2. Moosmann, B., Bisel, P., and Auwärter, V. Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics. Drug Test Anal. 6(7-8), 757-763 (2014).

    3. Magro, L., Faccini, M., and Leone, R. Lormetazepam addiction. Neuropathology of drug addictions and substance misuse 273-283 (2016).