An LPA1 receptor antagonist
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ONO-7300243

Item No. 22052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl]-benzeneacetic acid
CAS Number
638132-34-0
Molecular Formula
C28H31NO5
Formula Weight
461.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml
SMILES
OC(CC1=CC=C(CN(CCCC2=CC=CC=C2)C(C3=CC(OC)=C(C)C(OC)=C3)=O)C=C1)=O
InChi Code
InChI=1S/C28H31NO5/c1-20-25(33-2)17-24(18-26(20)34-3)28(32)29(15-7-10-21-8-5-4-6-9-21)19-23-13-11-22(12-14-23)16-27(30)31/h4-6,8-9,11-14,17-18H,7,10,15-16,19H2,1-3H3,(H,30,31)
InChi Key
WGABOZPQOOZAOI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $44

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    5 mg

    $195

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    10 mg

    $344

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    25 mg

    $642

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    Product Description

    ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 = 0.16 µM).1 It is selective for LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively). ONO-7300243 dose-dependently reduces intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg) without affecting mean blood pressure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Terkado, M., Suzuki, H., Hashimura, K., et al. Discovery of ONO-7300243 from a novel class of lysophosphatidic acid receptor 1 antagonists: From hit to lead. ACS Med. Chem. Lett. 7(10), 913-918 (2016).