Pirlindole

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC₅₀s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).¹ It is selective for MAO-A over MAO-B (K_is = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.² Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC₅₀ value of 7.7 µM independent of MAO-A activity.³

WARNING This product is not for human or veterinary use.

1. Bruhwyler, J., Liégeois, J.F., and Géczy, J. Pirlindole: A selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties. Pharmacol. Res. 36(1), 23-33 (1997).

2. Morais, M., Santos, P.A., Mateus-Pinheiro, A., et al. The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition. J. Psychopharmacol. 28(12), 1178-1183 (2014).

3. Ulferts, R., de Boer, S.M., van der Linden, L., et al. Screening of a library of FDA-approved drugs identifies several enterovirus replication inhibitors that target viral protein ²C. Antimicrob. Agents Chemother. 60(5), 2627-2638 (2016).