An inhibitor of MAO-A
Related Products
Isomer(s)
22060Pirlindole
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(R)-(–)-Pirlindole (mesylate)

Item No. 43879

Product Insert (PDF)
Technical Information
Formal Name
2,3,3aR,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole, methanesulfonate
CAS Number
1821379-62-7
Synonyms
  • (R)-Pirlindole
Molecular Formula
C15H18N2 • CH3SO3H
Formula Weight
322.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CS(=O)(O)=O.CC1=CC=C2N(CCN[C@]3([H])CCC4)C3=C4C2=C1
InChi Code
InChI=1S/C15H18N2.CH4O3S/c1-10-5-6-14-12(9-10)11-3-2-4-13-15(11)17(14)8-7-16-13;1-5(2,3)4/h5-6,9,13,16H,2-4,7-8H2,1H3;1H3,(H,2,3,4)/t13-;/m1./s1
InChi Key
PVUYTBQAVAYLDE-BTQNPOSSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

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    10 mg

    $459

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    25 mg

    $742

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    Product Description

    (R)-(–)-Pirlindole is an inhibitor of monoamine oxidase A (MAO-A; IC50 = 0.43 µM).1 It is selective for MAO-A over MAO-B. (R)-(–)-Pirlindole (50 mg/kg) decreases immobility time in the forced swim test in mice. It also inhibits reserpine-induced palpebral ptosis in mice when administered at a dose of 25 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruhwyler, J., Liégeois, J.F., Gérardy, J., et al. Comparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques. Behav. Pharmacol. 9(8), 731-737 (1998).