An isoxazoline ectoparasiticide
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Fluralaner

Item No. 22061

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-benzamide
CAS Number
864731-61-3
Synonyms
  • A-1443
  • AH 252723
Molecular Formula
C22H17Cl2F6N3O3
Formula Weight
556.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml
λmax
265 nm
SMILES
CC1=CC(C2=NOC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)C2)=CC=C1C(NCC(NCC(F)(F)F)=O)=O
InChi Code
InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)
InChi Key
MLBZKOGAMRTSKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Fluralaner is an isoxazoline ectoparasiticide.1,2 It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.1 Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.2 Formulations containing fluralaner have been used in the prevention and treatment of parasitic infections in veterinary medicine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ozoe, Y., Asahi, M., Ozoe, F., et al. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem. Biophys. Res. Commun. 391(1), 744-749 (2010).

    2. Gassel, M., Wolf, C., Noack, S., et al. The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect Biochem. Mol. Biol. 45, 111-124 (2014).