A weak NK1 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Benzomalvin C

Item No. 22064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S)-rel-(+)-6'-methyl-3-phenyl-spiro[oxirane-2,7'(13'H)-quinazolino[3,2-a][1,4]benzodiazepine]-5',13'(6'H)-dione
CAS Number
157047-98-8
Molecular Formula
C24H17N3O3
Formula Weight
395.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C1C2=C(C=CC=C2)N=C3N1C(C=CC=C4)=C4C(N(C)[C@]35O[C@@H]5C6=CC=CC=C6)=O
InChi Code
InChI=1S/C24H17N3O3/c1-26-21(28)17-12-6-8-14-19(17)27-22(29)16-11-5-7-13-18(16)25-23(27)24(26)20(30-24)15-9-3-2-4-10-15/h2-14,20H,1H3/t20-,24-/m1/s1
InChi Key
TWDKBDSVUUKABK-HYBUGGRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $560

    Add
    Product Description

    Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 µg/ml in vitro.1 It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 µM for recombinant IDO.2 It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, H.H., Barrow, C.J., Sedlock, D.M., et al. Benzomalvins, new substance P inhibitors from a Penicillium sp. J. Antibiot. (Tokyo) 47(5), 515-522 (1994).

    2. Jang, J.-P., Jang, J.-H., Soung, N.-K., et al. Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315. J. Antibiot. (Tokyo) 65(4), 215-217 (2012).