A weak NK1 receptor antagonist
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Benzomalvin C

Item No. 22064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S)-rel-(+)-6'-methyl-3-phenyl-spiro[oxirane-2,7'(13'H)-quinazolino[3,2-a][1,4]benzodiazepine]-5',13'(6'H)-dione
CAS Number
157047-98-8
Molecular Formula
C24H17N3O3
Formula Weight
395.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C1C2=C(C=CC=C2)N=C3N1C(C=CC=C4)=C4C(N(C)[C@]35O[C@@H]5C6=CC=CC=C6)=O
InChi Code
InChI=1S/C24H17N3O3/c1-26-21(28)17-12-6-8-14-19(17)27-22(29)16-11-5-7-13-18(16)25-23(27)24(26)20(30-24)15-9-3-2-4-10-15/h2-14,20H,1H3/t20-,24-/m1/s1
InChi Key
TWDKBDSVUUKABK-HYBUGGRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $560

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    Product Description

    Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 µg/ml in vitro.1 It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 µM for recombinant IDO.2 It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, H.H., Barrow, C.J., Sedlock, D.M., et al. Benzomalvins, new substance P inhibitors from a Penicillium sp. J. Antibiot. (Tokyo) 47(5), 515-522 (1994).

    2. Jang, J.-P., Jang, J.-H., Soung, N.-K., et al. Benzomalvin E, an indoleamine 2,3-dioxygenase inhibitor isolated from Penicillium sp. FN070315. J. Antibiot. (Tokyo) 65(4), 215-217 (2012).