A depsipeptide antifungal
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PF-1163B

Item No. 22066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione
CAS Number
258871-60-2
Molecular Formula
C27H43NO5
Formula Weight
461.6
Purity
≥95%
Formulation (Request formulation change)
An oil
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
O=C(N(C)[C@H]1CC2=CC=C(OCCO)C=C2)CCCC[C@@H](C)CC[C@@H](CCCCC)OC1=O
InChi Code
InChI=1S/C27H43NO5/c1-4-5-6-10-24-15-12-21(2)9-7-8-11-26(30)28(3)25(27(31)33-24)20-22-13-16-23(17-14-22)32-19-18-29/h13-14,16-17,21,24-25,29H,4-12,15,18-20H2,1-3H3/t21-,24-,25+/m1/s1
InChi Key
PCRJJAXIHTZHNU-SDUSCBPUSA-N
Origin
Fungus/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $208

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    2.5 mg

    $828

    Add
    Cayman Chemical
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    Product Description

    PF-1163B is a depsipeptide antifungal isolated from Penicillium that inhibits ergosterol (ERG) synthesis (IC50 = 34 ng/ml).1,2 It inhibits growth of C. albicans (MIC = 32 µg/ml) but not of other Candida strains, A. fumigatus, or HepG2 cells.1 It acts synergistically with fluconazole (Item No. 11594) to reduce growth of azole-resistant C. albicans (MIC = 2 and 0.0016 µg/ml alone and in combination, respectively).3 PF-1163B is a hydroxy form of PF-1163A (Item No. 22065).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nose, H., Seki, A., Yaquchi, T., et al. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 53(1), 33-37 (2000).

    2. Sasaki, T., Nose, H., Hosoya, A., et al. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation. J. Antibiot. (Tokyo) 53(1), 38-44 (2000).

    3. Okabe, M., Sugita, T., Kinoshita, K., et al. Macrolides from a marine-derived fungus, Penicillium meleagrinum var. viridiflavum, showing synergistic effects with fluconazole against azole-resistant Candida albicans. J. Nat. Prod. 79(4), 1208-1212 (2016).