An ATP analog with antithrombic properties
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Cangrelor (sodium salt)

Item No. 22086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid], tetrasodium salt
CAS Number
163706-36-3
Synonyms
  • AR-C69931MX
Molecular Formula
C17H21Cl2F3N5O12P3S2 • 4Na
Formula Weight
864.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SCCC(F)(F)F)N=C3NCCSC)O[C@@H]1COP(OP(C(Cl)(Cl)P([O-])([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10-,11-,14-;;;;/m1..../s1
InChi Key
COWWROCHWNGJHQ-OPKBHZIBSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM).1 It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor.2,3 Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism.4 Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ingall, A.H., Dixon, J., Bailey, A., et al. Antagonists of the platelet P2T receptor: A novel approach to antithrombotic therapy. J. Med. Chem. 42(2), 213-220 (1999).

    2. Wallentin, L. P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use. Eur. Heart J. 30(16), 1964-1977 (2009).

    3. Remko, M., Remková, A., and Boer, R. A comparative study of molecular structure, pKa, lipophilicity, solubility, absorption and polar surface area of some antiplatelet drugs. Int. J. Mol. Sci. 17(3), 388 (2016).

    4. Przygodzki, T., Talar, M., Blazejczyk, A., et al. Quantification of the blood platelet reactivity in the ADP-induced model of non-lethal pulmonary thromboembolism in mice with the use of laser doppler flowmetry. PLoS One 11(1), e0146346 (2016).

    5. Laine, M., Paganelli, F., and Bonello, L. P2Y12-ADP receptor antagonists: Days of future and past. World J. Cardiol. 8(5), 327-332 (2016).