An internal standard for the quantification of citalopram
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Unlabeled Version(s)
14572Citalopram (hydrobromide)
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Citalopram-d4 (hydrobromide)

Item No. 22102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl-d4)-1,3-dihydro-5-isobenzofurancarbonitrile, monohydrobromide
CAS Number
1219803-58-3
Synonyms
  • Bonitrile-d4
  • Nitalapram-d4
  • Prepram-d4
Molecular Formula
C20H17D4FN2O • HBr
Formula Weight
409.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
CN(C)CCCC1(C2=C([2H])C([2H])=C(F)C([2H])=C2[2H])OCC3=CC(C#N)=CC=C31.Br
InChi Code
InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H/i5D,6D,7D,8D;
InChi Key
WIHMBLDNRMIGDW-VBMPRCAQSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $140

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    1 mg

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    Product Description

    Citalopram-d4 (hydrobromide) is intended for use an internal standard for the quantification of citalopram (Item No. 14572) by GC- or LC-MS. Citalopram is a selective serotonin reuptake inhibitor which is commonly prescribed as an antidepressant.1,2,3 It also acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Millan, M.J., Gobert, A., Rivet, J.-M., et al. Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of α2-adrenergic and serotonin2C receptors: A comparison with citalopram. Eur. J. Neurosci. 12(3), 1079-1095 (2000).

    2. Boothman, L.J., Mitchell, S.N., and Sharp, T. Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis. Neuropharmacology 50(6), 726-732 (2006).

    3. Bymaster, F.P., Zhang, W., Carter, P.A., et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl) 160(4), 353-361 (2002).

    4. Shytle, R.D., Silver, A.A., Lukas, R.J., et al. Nicotinic acetylcholine receptors as targets for antidepressants. Mol. Psychiatry 7(6), 525-535 (2002).