A selective serotonin reuptake inhibitor
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Citalopram (hydrobromide)

Item No. 14572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, monohydrobromide
CAS Number
59729-32-7
Synonyms
  • Bonitrile
  • Lu 10-171B
  • Nitalapram
  • Prepram
Molecular Formula
C20H21FN2O • HBr
Formula Weight
405.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
204, 238 nm
SMILES
CN(C)CCCC1(C2=CC=C(F)C=C2)OCC3=CC(C#N)=CC=C31
InChi Code
InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
InChi Key
WSEQXVZVJXJVFP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $152

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    500 mg

    $532

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    1 g

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    Product Description

    Citalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with an IC50 value of 1.8 nM for 5-HT reuptake in rat brain synaptosomes.1 It is selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM). Citalopram potentiates headweaving and tremor induced by 5-hydroxy-L-tryptophan (Item No. 20539) in mice (ED50s = 0.61 and 0.66 mmol/kg, respectively). It also acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM).2 Formulations containing citalopram have been used to treat depression. This product is also available as an analytical reference standard (Item No. 23252).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyttel, J., Bøgesø, K.P., Perregaard, J., et al. The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer. J. Neural Transm. Gen. Sect. 88(2), 157-160 (1992).

    2. Shytle, R.D., Silver, A.A., Lukas, R.J., et al. Nicotinic acetylcholine receptors as targets for antidepressants. Mol. Psychiatry 7(6), 525-535 (2002).