A thyroid hormone derivative
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3,5-Diiodothyroacetic Acid

Item No. 22108

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-hydroxyphenoxy)-3,5-diiodo-benzeneacetic acid
CAS Number
1155-40-4
Synonyms
  • Diac
  • NSC 90463
  • T2A
  • TA2
Molecular Formula
C14H10I2O4
Formula Weight
496.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
229, 289 nm
SMILES
OC(CC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1)=O
InChi Code
InChI=1S/C14H10I2O4/c15-11-5-8(7-13(18)19)6-12(16)14(11)20-10-3-1-9(17)2-4-10/h1-6,17H,7H2,(H,18,19)
InChi Key
KKJBNMLZBHFYAE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $75

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    25 mg

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    50 mg

    $333

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    100 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    3,5-Diiodothyroacetic acid is an acetic acid derivative of thyroxine (Item No. 14116).1,2,3 It inhibits copper-induced lipid peroxidation of LDL isolated from human plasma when used at a concentration of 1 µM.1 3,5-Diiodothyroacetic acid (5 mg/100 g diet) increases urinary and fecal excretion of sterols, as well as prevents high-fat diet-induced increases in liver lipid and cholesterol levels, in rats.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chomard, P., Seguin, C., Loireau, A., et al. Effects of iodotyrosines, thyronines, iodothyroacetic acids and thyromimetic analogues on in vitro copper-induced oxidation of low-density lipoproteins. Biochem. Pharmacol. 55(10), 1591-1601 (1998).

    2. Beher, W.T., and Baker, G.D. The effects of 3,5-diiodothyroacetic and 3,3', 5-triiodothyroacetic acids on the time course of steroid C-14 metabolism in the rat. Henry Ford Hosp. Med. J. 13(4), 427-433 (1965).

    3. Ruegamer, W.R., and Silverman, F.R. Thyroxine analogues and cholesterol metabolism: The prevention and reversal of elevated liver cholesterol and lipid concentrations in the cholesterol fed rat by dietary 3,5 diiodothyroacetic acid1. Endocrinology 68(4), 564-573 (1961).