An antagonist of the Smo receptor
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MRT10

Item No. 22138

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-benzamide
CAS Number
330829-30-6
Molecular Formula
C24H23N3O5S
Formula Weight
465.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.3 mg/ml
λmax
284 nm
SMILES
O=C(NC1=CC=CC(NC(NC(C2=CC(OC)=C(OC)C(OC)=C2)=O)=S)=C1)C3=CC=CC=C3
InChi Code
InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33)
InChi Key
KVQVEZQDNHMQJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $110

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    10 mg

    $183

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    25 mg

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    Product Description

    MRT10 is an antagonist of the Smoothened (Smo) receptor with an IC50 value of 0.64 μM in a luciferase reporter assay.1,2 It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manetti, F., Faure, H., Roudaut, H., et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol. Pharm. 78(4), 658-665 (2010).

    2. Solinas, A., Faure, H., Roudaut, H., et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J. Med. Chem. 55(4), 1559-1571 (2012).