An impurity found in risperidone
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Risperidone E-oxime

Item No. 22156

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-[4-[(E)-(2,4-difluorophenyl)(hydroxyimino)methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS Number
691007-09-7
Molecular Formula
C23H28F2N4O2
Formula Weight
430.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1N2C(CCCC2)=NC(C)=C1CCN3CCC(/C(C4=CC=C(F)C=C4F)=N\O)CC3
InChi Code
InChI=1S/C23H28F2N4O2/c1-15-18(23(30)29-10-3-2-4-21(29)26-15)9-13-28-11-7-16(8-12-28)22(27-31)19-6-5-17(24)14-20(19)25/h5-6,14,16,31H,2-4,7-13H2,1H3/b27-22+
InChi Key
BRCINVRBDDVLDW-HPNDGRJYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    500 µg

    $69

    Add

    1 mg

    $127

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    5 mg

    $558

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    10 mg

    $918

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    Product Description

    Risperidone E-oxime is a potential impurity found in commercial preparations of risperidone.1,2 Risperidone (Item No. 13629) is a longer-acting benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders.3,4 This second-generation antipsychotic was designed to antagonize both D2 and 5-HT2A receptors.5,6 It has little effect on cholinergic and β-adrenergic receptors but does affect α2-adrenergic and histamine H1 receptors.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bharathi, C., Chary, D.K., Kumar, M.S., et al. Identification, isolation and characterization of potential degradation product in risperidone tablets. J. Pharm. Biomed. Anal. 46(1), 165-169 (2008).

    2. Nejedly, T., Pilarova, P., Kastner, P., et al. Development and validation of rapid UHPLC method for determination of risperidone and its impurities in bulk powder and tablets. Int. J. Res. Pharm. Chem. 4(2), 261-266 (2014).

    3. Colpaert, F.C. Discovering risperidone: The LSD model of psychopathology. Nat. Rev. Drug Discov. 2, 315-320 (2003).

    4. Rainer, M.K. Risperidone long-acting injection: A review of its long term safety and efficacy. Neuropsychiatr. Dis. Treat. 4(5), 919-927 (2008).

    5. Edwards, J.G. Risperidone for schizophrenia. BMJ 308(6940), 1311-1312 (1994).

    6. Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14(2), 87-96 (1996).