A lipid-soluble form of vitamin B1
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Benfotiamine

Item No. 22192

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester
CAS Number
22457-89-2
Synonyms
  • Benzoylthiamine monophosphate
Molecular Formula
C19H23N4O6PS
Formula Weight
466.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1m NH4OH: 1 mg/mlDMSO: slightly soluble
λmax
243 nm
SMILES
C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SC(C2=CC=CC=C2)=O)\CCOP(O)(O)=O
InChi Code
InChI=1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13-
InChi Key
BTNNPSLJPBRMLZ-LGMDPLHJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $49

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    1 g

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    5 g

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    Cayman Chemical
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    Product Description

    Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine).1 In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions.2 In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.1,3 Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication.4 Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer's disease.5 It also improves spatial memory performance in the Morris water maze.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stracke, H., Hammes, H.P., Werkmann, D., et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp. Clin. Endocrinol. Diabetes 109(6), 330-336 (2001).

    2. Pomero, F., Molinar Min, A., La Selva, M., et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta. Diabetol. 38(3), 135-138 (2001).

    3. Babaei-Jadidi, R., Karachalias, N., Ahmed, N., et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 52(8), 2110-2120 (2003).

    4. Portari, G.V., Ovidio, P.P., Deminice, R., et al. Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Life Sci. 162, 21-24 (2016).

    5. Pan, X., Gong, N., Zhao, J., et al. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 133(Pt 5), 1342-1351 (2010).