Cysteamine (hydrochloride)

Cysteamine is a stable aminothiol with radioprotective activities.¹ It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.^1,2 Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.² In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.³ Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.⁴

WARNING This product is not for human or veterinary use.

1. Nelson, A. The protective effect of cysteamine on young mice exposed to roentgen rays. Acta. Radiol. 42(6), 485-493 (1954).

2. Devik, F., and Lothe, F. The effect of cysteamine, cystamine and hypoxia on mortality and bone marrow chromosome aberrations in mice after total body roentgen irradiation. Acta. Radiol. 44(3), 243-248 (1955).

3. Thoene, J.G., Oshima, R.G., Crawhall, J.C., et al. Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo. J. Clin. Invest. 58(1), 180-189 (1976).

4. Gahl, W.A., Schneider, J.A., Schulman, J.D., et al. Predicted reciprocal serum creatinine at age 10 years as a measure of renal function in children with nephropathic cystinosis treated with oral cysteamine. Pediatr. Nephrol. 4(2), 129-135 (1990).