An internal standard for the quantification of cysteamine
Related Products
Unlabeled Version(s)
22193Cysteamine (hydrochloride)
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Cysteamine-d4 (hydrochloride)

Item No. 33297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-ethanethiol-d4, monohydrochloride
CAS Number
1219805-04-5
Synonyms
  • β-Mercaptoethylamine-d4
Molecular Formula
C2H3D4NS • HCl
Formula Weight
117.6
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
NC([2H])([2H])C([2H])([2H])S.Cl
InChi Code
InChI=1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H/i1D2,2D2;
InChi Key
OGMADIBCHLQMIP-PBCJVBLFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $117

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    5 mg

    $456

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    Product Description

    Cysteamine-d4 is intended for use as an internal standard for the quantification of cysteamine (hydrochloride) (Item No. 22193) by GC- or LC-MS. Cysteamine is a stable aminothiol with radioprotective activities.1 It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.1,2 Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.2 In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.3 Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nelson, A. The protective effect of cysteamine on young mice exposed to roentgen rays. Acta. Radiol. 42(6), 485-493 (1954).

    2. Devik, F., and Lothe, F. The effect of cysteamine, cystamine and hypoxia on mortality and bone marrow chromosome aberrations in mice after total body roentgen irradiation. Acta. Radiol. 44(3), 243-248 (1955).

    3. Thoene, J.G., Oshima, R.G., Crawhall, J.C., et al. Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo. J. Clin. Invest. 58(1), 180-189 (1976).