An inhibitor of Src-PTK
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KX1-004

Item No. 22198

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide
CAS Number
518058-84-9
Molecular Formula
C16H13FN2O2
Formula Weight
284.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 2.5 mg/ml
λmax
289 nm
SMILES
FC1=CC=C2C(C=C(C(NCC3=CC=CC(O)=C3)=O)N2)=C1
InChi Code
InChI=1S/C16H13FN2O2/c17-12-4-5-14-11(7-12)8-15(19-14)16(21)18-9-10-2-1-3-13(20)6-10/h1-8,19-20H,9H2,(H,18,21)
InChi Key
TUIHIKXCMCXXJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM).1 It protects against a permanent threshold shift in the auditory threshold and against outer hair cell loss in chinchillas following noise exposure at 106 dB when used at 30, 50, or 100 µM on the round window membrane of the ear. KX1-004 (50 mg/kg) is also effective against chronic noise exposure when administered systemically in chinchillas.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harris, K.C., Hu, B., Hangauer, D., et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 208(1-2), 14-25 (2005).

    2. Bielefeld, E.C., Hynes, S., Pryznosch, D., et al. A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss. Noise Health 7(29), 24-30 (2005).