A natural steroid saponin
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Timosaponin AIII

Item No. 22236

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,5β,25S)-spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
CAS Number
41059-79-4
Synonyms
  • TAIII
Molecular Formula
C39H64O13
Formula Weight
740.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
λmax
244, 312 nm
SMILES
O[C@H]([C@H](O)[C@H]1O[C@@]2([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](CO)O[C@@]1([H])O[C@H]3CC[C@@]4(C)[C@@](CC[C@]5([H])[C@]4([H])CC[C@@]6(C)[C@@]5([H])C[C@@]7([H])[C@]6([H])[C@H](C)[C@]8(OC[C@@H](C)CC8)O7)([H])C3
InChi Code
InChI=1S/C39H64O13/c1-18-7-12-39(47-17-18)19(2)28-25(52-39)14-24-22-6-5-20-13-21(8-10-37(20,3)23(22)9-11-38(24,28)4)48-36-34(32(45)30(43)27(16-41)50-36)51-35-33(46)31(44)29(42)26(15-40)49-35/h18-36,40-46H,5-17H2,1-4H3/t18-,19-,20+,21-,22+,23-,24-,25-,26+,27+,28-,29+,30-,31-,32-,33+,34+,35-,36+,37-,38-,39+/m0/s1
InChi Key
MMTWXUQMLQGAPC-YXOKLLKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Timosaponin AIII (TAIII) is a steroidal saponin isolated from A. asphodeloides that has anticancer, anti-inflammatory, and antithrombotic activities and also improves learning and memory deficits in mice.1,2,3,4,5 It inhibits invasive activity and COX-2 gene expression induced by hepatocyte growth factor (HGF) in MDA-MB-231 breast cancer cells and B16-F10 melanoma cells in a concentration-dependent manner.4,5 TAIII (25 mg/kg) significantly reduces the number of metastatic nodules in B16-F10 melanoma cell-treated mice.4 Oral administration of TAIII reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-kB activation, and IL-1β, TNF-α, and IL-6 levels in mice.2 TAIII reduces mortality and venous thrombus weight in mice with acute thromboembolism.3 It inhibits acetylcholinesterase in vitro (AChE; IC50 = 35.4 μM) and improves scopolamine-induced learning and memory deficits in mice, as measured using the passive avoidance test and Morris water maze.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, B., Jung, K., and Kim, D.H. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacol. Biochem. Behav. 93(2), 121-127 (2009).

    2. Lim, S.M., Jeong, J.J., Kang, G.D., et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int. Immunopharmacol. 25(2), 493-503 (2015).

    3. Cong, Y., Wang, L., Peng, R., et al. Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptor. Sci. Rep. 6, 38757 (2016).

    4. Kim, K.M., Im, A.-R., Kim, S.H., et al. Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. Cancer Sci. 107(2), 181-188 (2016).

    5. Tsai, C.-H., Yang, C.-W., Wang, J.-Y., et al. Timosaponin AIII suppresses hepatocyte growth factor-induced invasive activity through sustained ERK activation in breast cancer MDA-MB-231 cells. Evid. Based Complement. Altnernat. Med. 2013, 421051 (2013).