A steroidal saponin with diverse biological activities
Related Products
Parent Compound(s)
22236Timosaponin AIII
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Timosaponin AI

Item No. 36174

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,5β,25S)-spirostan-3-yl β-D-galactopyranoside
CAS Number
68422-00-4
Synonyms
  • Sarsasapogenin-3-O-β-galactopyranoside
Molecular Formula
C33H54O8
Formula Weight
578.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5([C@](C[C@H](CC5)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O)CO)([H])CC4)C)([H])CC2)([H])O[C@]7(CC[C@@H](CO7)C)[C@H]3C
InChi Code
InChI=1S/C33H54O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h17-30,34-37H,5-16H2,1-4H3/t17-,18-,19+,20-,21+,22-,23-,24-,25+,26-,27-,28-,29+,30+,31-,32-,33+/m0/s1
InChi Key
ZNEIIZNXGCIAAL-MYNIFUFOSA-N
Origin
Plant/Anemarrhena asphodeloides
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

    $244

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    10 mg

    $365

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    25 mg

    $605

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    Product Description

    Timosaponin AI is a steroidal saponin that has been found in A. asphodeloides and has diverse biological activities.1,2,3 It is also a metabolite of timosaponin AIII (Item No. 22236).4 Timosaponin AI inhibits 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4; IC50s = 3.29, 36.43, and 33.25 µM, respectively).1,2 It reduces total cholesterol and triglyceride levels in 3T3-L1 differentiated adipocytes and increases glucose consumption in insulin-resistant BNL CL.2 mouse embryonic liver cells stimulated with insulin.2 Timosaponin AI is cytotoxic to NRK rat kidney epithelial and MOLM-13 acute myeloid leukemia (AML) cells (EC50s = 0.12 and 0.22 mM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, L., Lee, D.Y.-W., Shang, Y., et al. Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS. Phytomedicine 77, 153284 (2020).

    2. Jiang, S., Wu, X., Wang, Y., et al. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. Eur. J. Pharmacol. 882, 173272 (2020).

    3. Carpinteyro Díaz, A.E., Herfindal, L., Rathe, B.A., et al. Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L. Phytochemistry 164, 67-77 (2019).

    4. Sun, Y., Liu, L., Peng, Y., et al. Metabolites characterization of timosaponin AIII in vivo and in vitro by using liquid chromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 997, 236-243 (2015).