An internal standard for the quantification of hypoxanthine
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Unlabeled Version(s)
22254Hypoxanthine
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Hypoxanthine-d4

Item No. 36330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,9-dihydro-1,9-d2-6H-purin-6-one-2,8-d2
CAS Number
2483831-32-7
Synonyms
  • 6-Hydroxypurine-d4
Molecular Formula
C5D4N4O
Formula Weight
140.1
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1C2=C(N=C([2H])N2[2H])N([2H])C([2H])=N1
InChi Code
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)/i1D,2D/hD2
InChi Key
FDGQSTZJBFJUBT-OPTZXGQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $84

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    25 mg

    $194

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    50 mg

    $369

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    Product Description

    Hypoxanthine-d4 is intended for use as an internal standard for the quantification of hypoxanthine (Item No. 22254) by GC- or LC-MS. Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain.1 Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice.2 Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysunction, self-mutilation, and hyperuricemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biasibetti-Brendler, H., Schmitz, F., Pierozan, P., et al. Hypoxanthine induces neuroenergetic impairment and cell death in striatum of young adult Wistar rats. Mol. Neurobiol. 55(5), 4098-4106 (2018).

    2. Yong, T., Zhang, M., Chen, D., et al. Actions of water extract from Cordyceps militaris in hyperuricemic mice induced by potassium oxonate combined with hypoxanthine. J. Ethnopharmacol. 194, 403-411 (2016).