A potent inhibitor of JNK1
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DB07268

Item No. 22257

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-[(3-hydroxyphenyl)amino]-4-pyrimidinyl]amino]-benzamide
CAS Number
929007-72-7
Molecular Formula
C17H15N5O2
Formula Weight
321.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
λmax
275, 323 nm
SMILES
OC1=CC=CC(NC2=NC=CC(NC3=C(C(N)=O)C=CC=C3)=N2)=C1
InChi Code
InChI=1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)
InChi Key
QHPKKGUGRGRSGA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $209

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    25 mg

    $479

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    Product Description

    DB07268 is a potent inhibitor of JNK1 (IC50 = 9 nM) that binds to the ATP site of JNK1.1 It is selective for JNK1 over P38, ERK2, AKT1, CHK1, and PAK4 among others. DB07268 did not reduce phosphorylation of insulin resistance substrate 1 (IRS-1) in HEK293 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schütz, H. Benzodiazepines: A handbook. Basic data, analytical methods, pharmacokinetics, and comprehensive literature. 439 (1982).

    2. Simon-Szabó, S., Kokas, M., Greff, Z., et al. Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes. Bioorg. Med. Chem. Lett 26(2), 424-428 (2016).