A natural steroid glycoside with diverse effects
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Isomer(s)
29005Ginsenoside Rb3
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Ginsenoside Rb2

Item No. 22265

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β)-20-[(6-O-α-L-arabinopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
11021-13-9
Synonyms
  • Ginsenoside C
  • NSC 308878
Molecular Formula
C53H90O22
Formula Weight
1079.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@@H](O)CO4)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]5(C)CC[C@]6([H])[C@@](CC[C@H](O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C6(C)C)(C)[C@@]5([H])C1
InChi Code
InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1
InChi Key
NODILNFGTFIURN-GZPRDHCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities.1 It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IκBα in human umbilical vein endothelial cells (HUVECs).2 Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells.3 It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Item No. 10010338).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, Y., and Zhao, S. Progress in understanding of ginsenoside biosynthesis. Plant Biol. (Stuttg) 10(4), 415-421 (2008).

    2. Cho, Y.S., Kim, C.H., Ha, T.S., et al. Ginsenoside Rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J. Physiol. Pharmacol. 17(2), 133-137 (2013).

    3. Ha, S.E., Shin, D.H., Kim, H.D., et al. Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells. Naunyn Schmiedebergs Arch. Pharmacol. 382(1), 89-101 (2010).

    4. Kim, E.J., Lee, H.I., Chung, K.J., et al. The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Rep. 42(4), 194-199 (2009).