A steroid glycoside with diverse biological activities
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Isomer(s)
22265Ginsenoside Rb2
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Ginsenoside Rb3

Item No. 29005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside
CAS Number
68406-26-8
Synonyms
  • Ginsenoside IV
Molecular Formula
C53H90O22
Formula Weight
1079.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]5(C)CC[C@]6([H])[C@@](CC[C@H](O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C6(C)C)(C)[C@@]5([H])C1
InChi Code
InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1
InChi Key
NODILNFGTFIURN-USYOXQFSSA-N
Origin
Plant/Ginseng root
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Ginsenoside Rb3 is a steroid glycoside that has been found in Panax and has diverse biological activities.1,2,3,4,5 It inhibits JNK-mediated activation of NF-κB and apoptosis induced by oxygen-glucose deprivation (OGD) in H9c2 mouse cardiac myoblasts in vitro and reduces myocardial apoptosis and production of reactive oxygen species (ROS) in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 20 mg/kg.1,2 Ginsenoside Rb3 (10 and 20 mg/kg per day for 10 days) prevents increases in serum creatinine, blood urea nitrogen (BUN), and malondialdehyde (MDA) levels, and decreases in superoxide dismutase (SOD) activity and glutathione (GSH) levels, as well as inhibits renal cell apoptosis in a mouse model of nephrotoxicity induced by cisplatin (Item No. 13119).3 It decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer.4 Ginsenoside Rb3 also decreases immobility time in the forced swim and tail suspension tests, indicating antidepressant-like activity, in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, L., Liu, H., Xie, Z., et al. Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-κB pathway: A mouse cardiomyocyte model. PLoS One 9(8), e103628 (2014).

    2. Liu, X., Jiang, Y., Yu, X., et al. Ginsenoside-Rb3 protects the myocardium from ischemia-reperfusion injury via the inhibition of apoptosis in rats. Exp. Ther. Med. 8(6), 1751-1756 (2014).

    3. Xing, J.-J., Hou, J.-G., Ma, Z.-N., et al. Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. Cell Prolif. 52(4), e12627 (2019).

    4. Huang, G., Khan, I., Li, X., et al. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. Sci. Rep. 7(1), 12552 (2017).

    5. Cui, J., Jiang, L., and Xiang, H. Ginsenoside Rb3 exerts antidepressant-like effects in several animal models. J. Psychopharmacol. 26(5), 697-713 (2012).