An acaricide
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Product Type

Environmental Toxicology
Pesticides
Acaricides

Fluazuron

Item No. 22283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[[4-chloro-3-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]amino]carbonyl]-2,6-difluoro-benzamide
CAS Number
86811-58-7
Molecular Formula
C20H10Cl2F5N3O3
Formula Weight
506.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
257 nm
SMILES
FC1=C(C(NC(NC2=CC(OC3=C(Cl)C=C(C(F)(F)F)C=N3)=C(Cl)C=C2)=O)=O)C(F)=CC=C1
InChi Code
InChI=1S/C20H10Cl2F5N3O3/c21-11-5-4-10(29-19(32)30-17(31)16-13(23)2-1-3-14(16)24)7-15(11)33-18-12(22)6-9(8-28-18)20(25,26)27/h1-8H,(H2,29,30,31,32)
InChi Key
YOWNVPAUWYHLQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Fluazuron is an acaricide widely-used to control tick populations in cattle, sheep, and pigs.1,2 Fluazuron inhibits chitin formation limiting viable egg production and prevents immature ticks from moulting.1 It is effective against populations of R. microplus, R. sanguineus, S. scabei, and Y. pestis at host doses ranging from 1.5 to 100 mg/kg.1,3,4,5,6 Fluazuron does not effect populations of F. candida or O. gazella, alleviating concerns about non-specific insecticide activity.7,8 Resistance to fluazuron in certain R. microplus strains may be emerging.9

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bull, M.S., Swindale, S., Overend, D., et al. Suppression of Boophilus microplus populations with fluazuron--an acarine growth regulator. Aust. Vet. J. 74(6), 468-470 (1996).

    2. Gomes, L.V.C., Lopes, W.D.Z., Cruz, B.C., et al. Acaricidal effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), administered at different routes, against Rhipicephalus (Boophilus) microplus parasitizing cattle. Exp. Parasitol. 153, 22-28 (2015).

    3. de Oliveira, P.R., Calligaris, I.B., Roma, G.C., et al. Potential of the insect growth regulator, fluazuron, in the control of Rhipicephalus sanguineus nymphs (Latreille, 1806) (Acari: Ixodidae): Determination of the LD95 and LD50. Exp. Parasitol. 131(1), 35-39 (2012).

    4. Pasay, C., Rothwell, J., Mounsey, K., et al. An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs. Parasit. Vectors. 5:40, (2012).

    5. Davis, R.M., Cleugh, E., Smith, R.T., et al. Use of a chitin synthesis inhibitor to control fleas on wild rodents important in the maintenance of plague, Yersinia pestis, in California. J. Vector Ecol. 33(2), 278-284 (2008).

    6. Zortéa, T., Segat, J.C., Maccari, A.P., et al. Toxicity of four veterinary pharmaceuticals on the survival and reproduction of Folsomia candida in tropical soils. Chemosphere 173, 460-465 (2017).

    7. Kryger, U., Deschodt, C., Davis, A.L.V., et al. Effects of cattle treatment with a fluazuron pour-on on survival and reproduction of the dung beetle species Onthophagus gazella (Fabricius). Vet. Parasitol. 143(3-4), 380-384 (2007).

    8. Reck, J., Klafke, G.M., Webster, A., et al. First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides. Vet. Parasitol. 201(1-2), 128-163 (2014).