An integrin αVβ3 receptor antagonist
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Cilengitide (trifluoroacetate salt)

Item No. 22289

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl), trifluoroacetate salt
CAS Number
199807-35-7
Synonyms
  • EMD 121974
Molecular Formula
C27H40N8O7 • CF3COOH
Formula Weight
702.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
NC(NCCC[C@@H](C(NCC1=O)=O)NC([C@H](C(C)C)N(C)C([C@@H](CC2=CC=CC=C2)NC([C@@](CC(O)=O)([H])N1)=O)=O)=O)=N.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C27H40N8O7.C2HF3O2/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16;3-2(4,5)1(6)7/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30);(H,6,7)/t17-,18-,19+,22-;/m0./s1
InChi Key
WHJCSACXAPYNTG-LOPTWHKWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $158

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    10 mg

    $246

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    25 mg

    $567

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    Cayman Chemical
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    Product Description

    Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide and integrin αVβ3 receptor antagonist.1 It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG) cells, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml. Cilengitide (200 μg/animal per day) delays tumor implantation time, reduces tumor growth, and prolongs survival in a U87MG mouse model of glioblastoma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chatterjee, S., Matsumura, A., Schradermeier, J., et al. Human malignant glioma therapy using anti-αVβ3 integrin agents. J. Neurooncol. 46(2), 135-144 (2000).

    2. Yamada, S., Bu, X.-Y., Khankaldyyan, V., et al. Effect of the angiogenesis inhibitor cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 59(6), 1304-1312 (2006).