An internal standard for the quantification of posaconazole
Related Products
Unlabeled Version(s)
14737Posaconazole
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Posaconazole-d5

Item No. 22376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS Number
2649530-57-2
Synonyms
  • POS-d5
Molecular Formula
C37H37D5F2N8O4
Formula Weight
705.8
Purity
≥98% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: soluble
SMILES
O=C1N([C@H]([C@@H](O)C)C([2H])([2H])C([2H])([2H])[2H])N=CN1C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[C@@H]5CO[C@@](CN6C=NC=N6)(C7=CC=C(F)C=C7F)C5)C=C4)CC3
InChi Code
InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1/i1D3,3D2
InChi Key
RAGOYPUPXAKGKH-XNZXKHRISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $480

    Add

    1 mg

    $864

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Posaconazole-d5 is intended for use as an internal standard for the quantification of posaconazole (Item No. 14737) by GC- or LC-MS. Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.1 Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the synthesis of ergosterol (Item No. 19850), a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).

    2. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds. Antimicrob. Agents Chemother. 48(10), 3690-3696 (2004).