A quinidine metabolite
Related Products
Parent Compound(s)
20356Quinidine
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Quinidine N-oxide

Item No. 22381

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6'-methoxy-cinchonan-9S-ol 1-oxide
CAS Number
70116-00-6
Molecular Formula
C20H24N2O3
Formula Weight
340.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O[C@@H](C1=CC=NC2=CC=C(OC)C=C12)[C@](C[C@H]3[C@@H](C=C)C4)([H])[N@+]4(CC3)[O-]
InChi Code
InChI=1S/C20H24N2O3/c1-3-13-12-22(24)9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(25-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-,22+/m0/s1
InChi Key
WVDIZKMXQMCCAA-ROCUERRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $85

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    1 mg

    $152

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    5 mg

    $548

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    Product Description

    Quinidine N-oxide is a pharmacologically inactive quinidine metabolite of quinidine (Item No. 20356).1 Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 isoforms CYP3A4, CYP2C9, and CYP2E1, with CYP3A4 being the most active enzyme in quinidine N-oxide formation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ha, H.-R., Vozeh, S., Uematsu, T., et al. Kinetics and dynamics of quinidine-N-oxide in healthy subjects. Clin. Pharmacol. Ther. 42(3), 341-345 (1987).

    2. Nielsen, T.L., Rasmussen, B.B., Flinois, J.-P., et al. In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes. J. Pharmacol. Exp. Ther. 289(1), 31-37 (1999).