An inhibitor of the Lin28/let-7 interaction
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Lin28 1632

Item No. 22401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-acetamide
CAS Number
108825-65-6
Molecular Formula
C15H15N5O
Formula Weight
281.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
247, 285 nm
SMILES
CN(C(C)=O)C1=CC=CC(C(C=C2)=NN3C2=NN=C3C)=C1
InChi Code
InChI=1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
InChi Key
WPAQLESUVYGUJZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $70

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    10 mg

    $97

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    50 mg

    $413

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    Cayman Chemical
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    Product Description

    Lin28 1632 is a small molecule inhibitor of the interaction between the RNA binding protein Lin28 and let-7 precursor RNA (IC50 = 8 μM in a competition ELISA).1 It increases levels of endogenous let-7 miRNAs and decreases Lin28 expression in a dose-dependent manner in murine embryonic stem cells (mESCs). Lin28 1632 inhibits clonogenic growth of 22Rv1, PC3, DU145, and Huh7 cancer cells and decreases tumor-sphere formation by 22Rv1 and Huh7 cells in vitro. It also binds bromodomain-containing protein 4 (BRD4) and CREB-binding protein (CBP/CREBBP) bromodomains (Kds = 7 and 25 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roos, M., Pradère, U., Ngondo, R.P., et al. A small-molecule inhibitor of Lin28. ACS Chem Biol. 11(10), 2773-2781 (2016).