A SIRT3 inhibitor
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CAY10722

Item No. 22404

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-benzeneacetamide
CAS Number
388086-13-3
Molecular Formula
C21H14Cl2N2O2
Formula Weight
397.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: Slightly soluble
λmax
211, 242, 315 nm
SMILES
ClC(C=C(Cl)C=C1)=C1C2=NC3=CC(NC(CC4=CC=CC=C4)=O)=CC=C3O2
InChi Code
InChI=1S/C21H14Cl2N2O2/c22-14-6-8-16(17(23)11-14)21-25-18-12-15(7-9-19(18)27-21)24-20(26)10-13-4-2-1-3-5-13/h1-9,11-12H,10H2,(H,24,26)
InChi Key
HUGVXMJZAPFVHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

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    Product Description

    CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM).1 SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.2,3 High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.4 In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salo, H.S., Latinen, T., Poso, A., et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. Bioorg. Med. Chem. Lett. 23(10), 2990-2995 (2013).

    2. Chen, Y., Fu, L., Wen, X., et al. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer. Cell Death Dis. 5(e1047), 1-7 (2014).

    3. Xiong, Y., Wang, M., Zhao, J., et al. Sirtuin 3: A Janus face in cancer (Review). Int. J. Oncol. 49(6), 2227-2235 (2016).

    4. Zhao, Y., Yang, H., Wang, X., et al. Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer. Ann. Diagn. Pathol. 17(6), 483-485 (2013).

    5. Desouki, M.M., Doubinskaia, I., Gius, D., et al. Decreased mitochondrial SIRT3 expression is potential molecular biomarker associated with poor outcome in breast cancer. Hum. Pathol. 45(5), 1071–1077 (2014).