A bioactive saponin from Astragalus
Related Products
Isomer(s)
40279Isoastragaloside I
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Astragaloside I

Item No. 22431

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,16β,20R,24S)-3-[(2,3-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside
CAS Number
84680-75-1
Synonyms
  • AS-I
  • AST-I
Molecular Formula
C45H72O16
Formula Weight
869.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 30 mg/mLDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@](O[C@H]2C[C@]([C@@](C[C@H](O)[C@]3([H])[C@]4(C)O[C@H](C(C)(O)C)CC4)(C)[C@]3(C)CC5)([H])[C@]56[C@]7(C6)[C@]2([H])C(C)(C)[C@@H](O[C@]8([H])OC[C@@H](O)[C@H](OC(C)=O)[C@H]8OC(C)=O)CC7)([H])[C@@H]1O
InChi Code
InChI=1S/C45H72O16/c1-21(47)56-33-24(50)19-55-38(34(33)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5,6)54)23(49)17-42(41,8)27(44)16-25(36(45)39(28,3)4)58-37-32(53)31(52)30(51)26(18-46)59-37/h23-38,46,49-54H,10-20H2,1-9H3/t23-,24+,25-,26+,27-,28-,29-,30+,31-,32+,33-,34+,35-,36-,37+,38-,41+,42-,43+,44-,45+/m0/s1
InChi Key
KXHCYYSIAXMSPA-OOCCOBHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $50

    Add

    5 mg

    $147

    Add

    10 mg

    $266

    Add

    25 mg

    $543

    Add
    Product Description

    Astragaloside I is a saponin originally isolated from the dried plant roots of Astragalus, which is used in traditional Chinese medicine.1 Astragaloside I has osteogenic activities in vitro.2 It induces differentiation and matrix mineralization of MC3T3-E1 cells, a murine osteoblastic cell line, and increases alkaline phosphatase activity. It also increases the expression of osteoblast-related genes in a concentration-dependent manner (10-40 µM), including genes in the Wnt/β-catenin pathway.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, S., Zhang, H., Mu, Y., et al. Pharmacological effects of Astragaloside IV: A literature review. J. Tradit. Chin. Med. 33(3), 413-416 (2013).

    2. Chang, X., Wei, B., Sun, L., et al. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway. Phytother. Res. 30(10), 1680-1688 (2016).