A bioactive saponin from Astragalus
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Isomer(s)
40279Isoastragaloside I
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Astragaloside I

Item No. 22431

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,16β,20R,24S)-3-[(2,3-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside
CAS Number
84680-75-1
Synonyms
  • AS-I
  • AST-I
Molecular Formula
C45H72O16
Formula Weight
869.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 30 mg/mLDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@](O[C@H]2C[C@]([C@@](C[C@H](O)[C@]3([H])[C@]4(C)O[C@H](C(C)(O)C)CC4)(C)[C@]3(C)CC5)([H])[C@]56[C@]7(C6)[C@]2([H])C(C)(C)[C@@H](O[C@]8([H])OC[C@@H](O)[C@H](OC(C)=O)[C@H]8OC(C)=O)CC7)([H])[C@@H]1O
InChi Code
InChI=1S/C45H72O16/c1-21(47)56-33-24(50)19-55-38(34(33)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5,6)54)23(49)17-42(41,8)27(44)16-25(36(45)39(28,3)4)58-37-32(53)31(52)30(51)26(18-46)59-37/h23-38,46,49-54H,10-20H2,1-9H3/t23-,24+,25-,26+,27-,28-,29-,30+,31-,32+,33-,34+,35-,36-,37+,38-,41+,42-,43+,44-,45+/m0/s1
InChi Key
KXHCYYSIAXMSPA-OOCCOBHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $266

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    25 mg

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    Product Description

    Astragaloside I is a saponin originally isolated from the dried plant roots of Astragalus, which is used in traditional Chinese medicine.1 Astragaloside I has osteogenic activities in vitro.2 It induces differentiation and matrix mineralization of MC3T3-E1 cells, a murine osteoblastic cell line, and increases alkaline phosphatase activity. It also increases the expression of osteoblast-related genes in a concentration-dependent manner (10-40 µM), including genes in the Wnt/β-catenin pathway.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, S., Zhang, H., Mu, Y., et al. Pharmacological effects of Astragaloside IV: A literature review. J. Tradit. Chin. Med. 33(3), 413-416 (2013).

    2. Chang, X., Wei, B., Sun, L., et al. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway. Phytother. Res. 30(10), 1680-1688 (2016).