Aloin

Aloin is a mixture of aloin A and aloin B (Item No. 23321), anthraquinones found in Aloe vera, and has diverse biological activities.^1,2,3 It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.¹ Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.² Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.³

WARNING This product is not for human or veterinary use.

1. Luo, X., Zhang, H., Wei, X., et al. Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of NF-κB. Molecules 23(3), E517 (2018).

2. Tewabe, Y., Bisrat, D., Terefe, G., et al. Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate. BMC Vet. Res. 10, 61 (2014).

3. Hamiza, O.O., Rehman, M.U., Khan, R., et al. Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats. Hum. Exp. Toxicol. 33(2), 148-163 (2014).