Isoliquiritin

Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.^1,2,3 It inhibits LPS-induced nitrite and prostaglandin E₂ (PGE₂; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.¹ Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.² In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED₅₀s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.³

WARNING This product is not for human or veterinary use.

1. Kim, J.Y., Park, S.J., Yun, K.J., et al. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7 macrophages. Eur. J. Pharmacol. 584(1), 175-184 (2008).

2. Kobayashi, S., Miyamoto, T., Kimura, I., et al. Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. Biol. Pharm. Bull. 18(10), 1382-1386 (1995).

3. Wang, W., Hu, X., Zhao, Z., et al. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 32(5), 1179-1184 (2008).