An active metabolite of diclofenac
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Diclofenac Acyl-β-D-Glucuronide

Item No. 22455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-D-glucopyranuronic acid, 1-[2-[(2,6-dichlorophenyl)amino]benzeneacetate]
CAS Number
64118-81-6
Synonyms
  • Diclofenac Glucuronide
  • Diclofenac-β-D-glucuronide
Molecular Formula
C20H19Cl2NO8
Formula Weight
472.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
λmax
277 nm
SMILES
ClC1=CC=CC(Cl)=C1NC2=C(CC(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=O)C=CC=C2
InChi Code
InChI=1S/C20H19Cl2NO8/c21-10-5-3-6-11(22)14(10)23-12-7-2-1-4-9(12)8-13(24)30-20-17(27)15(25)16(26)18(31-20)19(28)29/h1-7,15-18,20,23,25-27H,8H2,(H,28,29)/t15-,16-,17+,18-,20+/m0/s1
InChi Key
JXIKYYSIYCILNG-HBWRTXEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    Diclofenac acyl-β-D-glucuronide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor diclofenac (Item Nos. 70680 | 22983).1 It is formed from diclofenac via UDP-glucuronosyltransferase (UGT) isoform UGT2B7.2 Diclofenac acyl-β-D-glucuronide inhibits the proliferation of HT-29 colorectal adenocarcinoma cells (IC50 = 130 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, J.R., Maggs, J.L., Meng, X., et al. Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. J. Med. Chem. 47(11), 2816-2825 (2004).

    2. King, C., Tang, W., Ngui, J., et al. Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac. Toxicol. Sci. 61(1), 49-53 (2001).

    3. Cannell, G.R., Vesey, D.A., and Dickinson, R.G. Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides. Life Sci. 70(1), 37-48 (2001).