An NSAID and a COX inhibitor
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Diclofenac (sodium salt)

Item No. 70680

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, monosodium salt
CAS Number
15307-79-6
Molecular Formula
C14H10Cl2NO2 • Na
Formula Weight
318.1
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 40 mg/mlEthanol: 35 mg/mlPBS (pH 7.2): 9 mg/ml
λmax
285 nm
SMILES
ClC1=C(N([H])C2=C(CC([O-])=O)C=CC=C2)C(Cl)=CC=C1.[Na+]
InChi Code
InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChi Key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $35

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    25 g

    $68

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    50 g

    $116

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    100 g

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    Product Description

    Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively).1,2 It is also an active metabolite of diclofenac methyl ester (Item No. 22218) and diclofenac amide (Item No. 21969).3,4 Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 (Item No. 11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively).5 Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats.6 Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271(2), 927-934 (1994).

    2. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    3. Lobo, S., Li, H., Farhan, N., et al. Evaluation of diclofenac prodrugs for enhancing transdermal delivery. Drug Dev. Ind. Pharm. 40(3), 425-432 (2014).

    4. Santos, J., Moreira, V., Campos, M.L., et al. Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. Int. J. Mol. Sci. 13(11), 15305-15320 (2012).

    5. Kothari, H.V., Lee, W.H., and Ku, E.C. An alternate mechanism for regulation of leukotriene production in leukocytes: studies with an anti-inflammatory drug, sodium diclofenac. Biochim. Biophys. Acta 921(3), 502-511 (1987).

    6. Arora, P., and Mukherjee, B. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt. J. Pharm. Sci. 91(9), 2076-2089 (2002).

    Product Citations

    d'Alencon, C.A., Peña, O.A., Wittmann, C., et al. A high-throughput chemically induced inflammation assay in zebrafish. BMC Biol. 8, 151 (2010).