An LTB4 antagonist
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Ricinelaidic Acid

Item No. 22470

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12(R)-hydroxy-9(E)-octadecenoic acid
CAS Number
540-12-5
Molecular Formula
C18H34O3
Formula Weight
298.5
Purity
≥95%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 2 mg/mlEthanol: MisciblePBS (pH 7.2): 2 mg/ml
SMILES
O[C@H](CCCCCC)C/C=C/CCCCCCCC(O)=O
InChi Code
InChI=1S/C18H34O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h9,12,17,19H,2-8,10-11,13-16H2,1H3,(H,20,21)/b12-9+/t17-/m1/s1
InChi Key
WBHHMMIMDMUBKC-XLNAKTSKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $69

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    50 mg

    $127

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    100 mg

    $238

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    250 mg

    $525

    Add
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    Product Description

    Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 µM in porcine neutrophil membranes).1 It inhibits chemotaxis and calcium flux induced by LTB4 (Item No. 20110) in isolated human neutrophils (IC50s = 10 and 7 µM, respectively). Ricinelaidic acid (1 mg/kg, i.v.) inhibits bronchoconstriction induced by LTB4 in rats by 46%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).