A calcium channel blocker
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Mirogabalin

Item No. 22475

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo[3.2.0]hept-3-ene-6-acetic acid
CAS Number
1138245-13-2
Synonyms
  • DS-5565
Molecular Formula
C12H19NO2
Formula Weight
209.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 0.5 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
CCC1=C[C@]([C@](CC(O)=O)(CN)C2)([H])[C@]2([H])C1
InChi Code
InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
InChi Key
FTBQORVNHOIASH-CKYFFXLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $168

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    Product Description

    Mirogabalin is a calcium channel blocker with analgesic effects.1 It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; Item No. 13104). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, K., Ohwada, S., Warren, V., et al. (405) A single ascending-dose study of mirogabalin in healthy subjects: Safety, tolerability, pharmacokinetic, and pharmacodynamic results. J. Pain 17(4S), S76 (2016).