An antagonist of TNF-α receptor signaling
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R-8507

Item No. 22479

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
CAS Number
338773-13-0
Molecular Formula
C16H8ClF3N4
Formula Weight
348.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 2 mg/ml
λmax
219, 247 nm
SMILES
ClC(C=C1)=CC=C1C2=NN=C3N2C4=C(C=CC=C4)N=C3C(F)(F)F
InChi Code
InChI=1S/C16H8ClF3N4/c17-10-7-5-9(6-8-10)14-22-23-15-13(16(18,19)20)21-11-3-1-2-4-12(11)24(14)15/h1-8H
InChi Key
PEOTYDSXVIEYAM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

    $351

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    25 mg

    $775

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    Cayman Chemical
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    Product Description

    R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).1 It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem. Biol. 14(10), 1105-1118 (2007).